Related pages Drug Information Summaries 1 Approval Process for New Cancer Treatments 2 Access to Investigational Drugs 3

This page contains brief information about bortezomib and a collection of links to more information about the use of this drug, related news and research results, and ongoing clinical trials.

US Brand Name(s):		VELCADE
FDA Approved:		Yes

Bortezomib is approved by the Food and Drug Administration (FDA) to treat multiple myeloma. It is also approved to treat mantle cell lymphoma in patients who have already received at least one other type of treatment.

Bortezomib is also being studied in the treatment of other types of cancer.

FDA Approval for Bortezomib ⁴ - Information from the FDA about the approval of this drug and the clinical trials that led to the approval.

Definition from the NCI Drug Dictionary ⁵ - Detailed scientific definition and other names for this drug.

Clinical Trial Results: Bortezomib Approved for First-Line Treatment of Multiple Myeloma (09/11/2008) ⁶ - Important clinical trial results for this drug, background information, and how the trial was done.

Clinical Trial Results: Drug Combination Shows Benefit in Relapsed/Refractory Multiple Myeloma (08/28/2007) ⁷ - Important clinical trial results for this drug, background information, and how the trial was done.

Clinical Trial Results: Bortezomib Delays Progression of Multiple Myeloma Longer than Standard Therapy: Results of the APEX Trial (06/05/2004) ⁸ - Important clinical trial results for this drug, background information, and how the trial was done.

Compounds Found in Green Tea Block Bortezomib (02/24/2009) ⁹ - Information about the use of this drug to treat cancer.

MedlinePlus Information on Bortezomib ¹⁰ - A lay language summary of important information about this drug that may include the following:

• warnings about this drug,
• what this drug is used for and how it is used,
• what you should tell your doctor before using this drug,
• what you should know about this drug before using it,
• other drugs that may interact with this drug, and
• possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This NLM patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Clinical Trials for Bortezomib ¹¹ - Check for trials from NCI's PDQ Cancer Clinical Trials Registry now accepting patients.

Glossary Terms

A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.

An agency in the U.S. federal government whose mission is to protect public health by making sure that food, cosmetics, and nutritional supplements are safe to use and truthfully labeled. The Food and Drug Administration also makes sure that drugs, medical devices, and equipment are safe and effective, and that blood for transfusions and transplant tissue are safe. Also called FDA.

An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that usually occurs in middle-aged or older adults. It is marked by small- to medium-size cancer cells that may be in the lymph nodes, spleen, bone marrow, blood, and gastrointestinal system.

A type of cancer that begins in plasma cells (white blood cells that produce antibodies). Also called Kahler disease, myelomatosis, and plasma cell myeloma.