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Genetics of Prostate Cancer (PDQ®)
Health Professional VersionLast Modified: 06/19/2008
Table 1. Relative Risk Related to Family History of Prostate Cancer

Risk Group  Relative Risk for Prostate Cancer 
Adapted from Zeegers et al.[29]
Brother with prostate cancer diagnosed at any age 3.4 (95% CI, 3.0–3.8)
Father with prostate cancer diagnosed at any age 2.2 (95% CI, 1.9–2.5)
One affected first-degree relative diagnosed at any age 2.6 (95% CI, 2.3–2.8)
One affected second-degree relative diagnosed at any age 1.7 (95% CI, 1.1–2.6)
Affected first-degree relative(s) diagnosed age <65 years 3.3 (95% CI, 2.6–4.2)
Affected first-degree relative(s) diagnosed age >65 years 2.4 (95% CI, 1.7–3.6)
Two or more affected first-degree relatives diagnosed at any age 5.1 (95% CI, 3.3–7.8)

References

  1. Zeegers MP, Jellema A, Ostrer H: Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: a meta-analysis. Cancer 97 (8): 1894-903, 2003.  [PUBMED Abstract]


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