The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Overview ¹

Added text ² on depression and anxiety disorders in palliative cancer care (cited Wilson et al. as reference 12).

Added text ³ on the pathophysiology of cancer-related depression (cited Jehn et al. as reference 24).

Intervention ⁴

Added text ⁵ to state that age-stratified analyses of child and adolescent studies found that for children younger than 12 years with major depression, only fluoxetine showed benefit over placebo (cited Bridge et al. as reference 23).

Pediatric Considerations for Depression ⁶

Added text ⁷ on risk-benefit analyses and the appropriate use of antidepressants in children and adolescents (cited Bridge et al. as reference 23, Hammad et al. as reference 24, Gibbons et al. as reference 25, and Leon as reference 26).