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Treatment Options for Childhood Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Juvenile Myelomonocytic Leukemia
Newly Diagnosed Childhood Acute Myeloid Leukemia
Childhood Acute Myeloid Leukemia in Remission
Recurrent Childhood Acute Myeloid
Leukemia
Acute Promyelocytic Leukemia
Children with Down Syndrome and AML
Childhood Chronic Myelogenous Leukemia
Juvenile Myelomonocytic Leukemia
Transient Myeloproliferative Disorder
Myelodysplastic Syndromes
A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.
Newly Diagnosed Childhood Acute Myeloid Leukemia
Treatment of newly diagnosed childhood acute myeloid leukemia (AML) is combination chemotherapy. CNS sanctuary therapy is intrathecal chemotherapy with or without radiation therapy to the brain.
Treatment of newly diagnosed childhood acute leukemia with a granulocytic sarcoma (chloroma) may include chemotherapy with or without radiation therapy.
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with untreated childhood acute myeloid leukemia and other myeloid malignancies.
Childhood Acute Myeloid Leukemia in Remission
Treatment of childhood acute myeloid leukemia (AML) during the remission phase (consolidation /intensification therapy) depends on the subtype of AML and may include the following:
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with childhood acute myeloid leukemia in remission.
Recurrent Childhood Acute Myeloid
Leukemia
Treatment of recurrent childhood acute myeloid leukemia (AML) may
include the following:
Treatment of recurrent acute promyelocytic leukemia may include all-trans retinoic acid (ATRA) or arsenic trioxide therapy
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with recurrent childhood acute myeloid leukemia.
Acute Promyelocytic Leukemia
Treatment of acute promyelocytic leukemia may include the following:
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with childhood acute promyelocytic leukemia (M3).
Children with Down Syndrome and AML
Treatment of AML in children who have Down syndrome may include the following:
Childhood Chronic Myelogenous Leukemia
Treatment for childhood chronic myelogenous leukemia may include the following:
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with childhood chronic myelogenous leukemia.
Juvenile Myelomonocytic Leukemia
Treatment of juvenile myelomonocytic leukemia may include the following:
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with juvenile myelomonocytic leukemia.
Transient Myeloproliferative Disorder
Transient myeloproliferative disorder (TMD) usually goes away on its own. For TMD that does not go away on its own, treatment may include the following:
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with acute myeloid leukemia/transient myeloproliferative disorder.
Myelodysplastic Syndromes
Treatment of myelodysplastic syndromes may include the following:
Supportive care treatments are used to manage problems caused by the disease, such as infection, bleeding, and anemia.
If the myelodysplastic syndrome progresses to acute myeloid leukemia (AML), treatment will be the same as treatment for the newly diagnosed patient with AML.
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with childhood myelodysplastic syndromes.
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