 |
|
|
Table 4: Type of Germ Cell Tumor by Stage and by Risk Group*
|
|
Ovarian
|
Testicular
|
Extragonadal
|
| Stage I |
Low |
Low |
Intermediate |
| Stage II |
Intermediate |
Intermediate |
Intermediate |
| Stage
III |
Intermediate |
Intermediate |
High |
| Stage
IV |
High** |
Intermediate*** |
High |
|
*Adapted from Rogers PC et al.[6] and Cushing B et al.[7]
|
|
**Stage IV ovarian tumors in children and adolescents continue to be treated with four courses of pediatric PEB; these patients are not eligible for either a possible reduction in treatment courses, as are the intermediate-risk patients, or the high-risk protocol that includes the potential of greater toxicity.
|
|
***Stage IV testicular tumors in patients older than 15 years should be staged according to adult guidelines. For more information, please refer to the PDQ summary Testicular Cancer Treatment.
|
References
-
Rogers PC, Olson TA, Cullen JW, et al.: Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: A Pediatric Intergroup Study--Pediatric Oncology Group 9048 and Children's Cancer Group 8891. J Clin Oncol 22 (17): 3563-9, 2004.
[PUBMED Abstract]
-
Cushing B, Giller R, Cullen JW, et al.: Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study--Pediatric Oncology Group 9049 and Children's Cancer Group 8882. J Clin Oncol 22 (13): 2691-700, 2004.
[PUBMED Abstract]
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|
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