The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Prognostic Factors ¹

Added Fernandes et al. as reference 5 ².

Added text ³ to state that not every nodule detected indicates metastatic disease.

Added text ³ to state that patients with less necrosis (<90%) in the primary tumor following initial chemotherapy have a higher rate of recurrence within the first 2 years (cited Kim et al. as reference 25).

Added Heinsohn et al. as reference 43 ⁴.

Added text ⁴ to state that malignant fibrous histiocytoma of bone is seen more commonly in older adults.

Staging and Site Information ⁵

Added text ⁶ about the Enneking staging system for musculoskeletal neoplasms and the basis for the system (Enneking et al. as reference 1).

Localized Osteosarcoma/Malignant Fibrous Histiocytoma of Bone ⁷

Added text ⁸ to state that in a large Cooperative Osteosarcoma Study Group trial, higher chemotherapy dose intensity did not correlate with improved outcome (cited Eselgrim et al. as reference 18).

Metastatic Disease at Diagnosis ⁹

Added text ¹⁰ to state that high dose ifosfamide in combination with etoposide produced a complete or partial response in patients with newly diagnosed metastatic osteosarcoma (cited Goorin et al. as reference 7).

Recurrent Osteosarcoma ¹¹

Added text ¹² to state that the incidence of local relapse was higher in patients who had a poor pathologic response to chemotherapy in the primary tumor and in patients with inadequate surgical margins (cited Bacci et al. as reference 23).

Added Berrak et al. as reference 29 ¹³.