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Recurrent Major Salivary Gland Cancer
Current Clinical Trials
The prognosis for any treated cancer patient with progressing or relapsing
disease is poor, regardless of cell type or stage. Selecting further treatment
depends on many factors, including the specific cancer, prior treatment, site
of recurrence, and individual patient considerations. Fast neutron-radiation therapy is superior to conventional radiation
therapy using x-rays and may be curative in selected cases of recurrent
disease.[1]
Disease-free and overall survival for patients with inoperable,
unresectable, or recurrent malignant salivary gland tumors is superior in
patients treated with fast neutron radiation as compared to those treated with conventional
x-ray radiation therapy.[2-5] Clinical trials are appropriate and should be
considered when possible.
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with recurrent salivary gland cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
References
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Laramore GE, Krall JM, Griffin TW, et al.: Neutron versus photon irradiation for unresectable salivary gland tumors: final report of an RTOG-MRC randomized clinical trial. Radiation Therapy Oncology Group. Medical Research Council. Int J Radiat Oncol Biol Phys 27 (2): 235-40, 1993.
[PUBMED Abstract]
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Laramore GE: Fast neutron radiotherapy for inoperable salivary gland tumors: is it the treatment of choice? Int J Radiat Oncol Biol Phys 13 (9): 1421-3, 1987.
[PUBMED Abstract]
-
Saroja KR, Mansell J, Hendrickson FR, et al.: An update on malignant salivary gland tumors treated with neutrons at Fermilab. Int J Radiat Oncol Biol Phys 13 (9): 1319-25, 1987.
[PUBMED Abstract]
-
Buchholz TA, Laramore GE, Griffin BR, et al.: The role of fast neutron radiation therapy in the management of advanced salivary gland malignant neoplasms. Cancer 69 (11): 2779-88, 1992.
[PUBMED Abstract]
-
Krüll A, Schwarz R, Engenhart R, et al.: European results in neutron therapy of malignant salivary gland tumors. Bull Cancer Radiother 83 (Suppl): 125-9s, 1996.
[PUBMED Abstract]
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