The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Purpose of This PDQ Summary

Added text to state that some reference citations in the summary are accompanied by a level-of-evidence designation that is intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches.

Head and Neck Cancers

Added text to state that the PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy; added a link to the PDQ summary on Levels of Evidence.

Added text to state that a chemotherapy regimen of carboplatin, epirubicin, vincristine, etoposide, ifosfamide, and dactinomycin has been used in the treatment of metastatic sialoblastoma and has produced a response in one child (cited Scott et al. as reference 71 and added level of evidence: 3iiiDiv).

Thoracic Cancers

Added text to state that the PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy; added a link to the PDQ summary on Levels of Evidence.

Added Coulter et al. as reference 47.

Abdominal Cancers

Added text to state that the PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy; added a link to the PDQ summary on Levels of Evidence.

Added text to state that postoperative treatment with cisplatin, doxorubicin, ifosfamide, and etoposide has produced responses in patients with pancreatoblastoma (cited Lee et al. as reference 41 and added level of evidence: 3iiiA).

Added Hill et al. as reference 51 and level of evidence: 3iiiA.

Other Rare Childhood Cancers

Added protocol NCI-07-C-0189 as a treatment option under clinical evaluation (cited Herbst et al. and Vidal et al. as references 22 and 23, respectively).

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