Leukocyte Cell Biology Section

Laboratory of Experimental Immunology, National Cancer Institute, National Institutes of Health.

Recent Publications


Taub, D.D., Ortaldo, J.R., Turcovski-Corrales, S.M., Key, M.L., Longo, D.L., and Murphy, W.J.: Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production.. J. Leukoc. Biol. 59:81-89, 1996.

McVicar, D.W., Blake, T.B., Burns, C.M., Conlon, K.C., Ortaldo, J.R., and O'Shea, J.J.P: Differential basal protein tyrosine phosphorylation in natural killer (NK) and T cells; a biochemical correlate of lymphoid functional activity. Cell. Immunol. 169: 302-308, 1996.

Giardina, S.L., Coffman, J.D., Young, H.A., Potter, S.J., Frey, J.L., Ortaldo, J.R., and Anderson, S.K.: Association of the expression of an SR-cyclophilin with myeloid cell differentiation. Blood 87: 2269-2274, 1996.

Fogler, W.E., Volker, K., McCormick, K.L., Watanabe, M., Ortaldo, J.R., and Wiltrout, R.H.: NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156: 4707-4714, 1996.

Cox, G.W., Taylor, L.S., Willis, J.D., Melillo, G., White, R.L III, Anderson, S.K., and Lin, J-J.: Molecular cloning and characterization of a novel mouse macrophage gene that encodes a nuclearprotein comprising polyglutamine repeats and interspersing histidines. J. Biol. Chem. 271: 25515-25523, 1996.

Ortaldo, J.R., Mason, A.T., Longo, D.L., Beckwith, M., Creekmore, S.P., and McVicar, D.W.: T cell activation via the disialogonglioside, GD3: analysis of signal transduction. J. Leukoc. Biol.. 60: 533-539, 1996.

Mason, L.H., Anderson, S.K., Yokoyama, W.M., Smith, H.R.C., Winkler-Pickett, R., and Ortaldo, J.R.: The Ly-49D receptor activates murine NK cells. J. Exp. Med. 184:2119-2128, 1996.

Bosco, M.C., Rottschafer, S., Taylor, L.S., Ortaldo, J.R., Longo, D.L., and Espinoza-Delgado, I.: The antineoplastic agent bryostatin-1 induces IL-1 , TNF , IL-8, and IL-6 mRNA expression and protein secretion in human monocytes. Synergy with IL-2 and modulation of IL-2R chain expression. Blood, 89(9) 3402-3411.

Grgurevich, S., Linnekin, D., Musso, T., Zhang, X., Modi, W., Varesio, L., Ruscetti, F.W., Ortaldo, J.R., and McVicar, D.W.: The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7E. Growth Factors, in press.

Ortaldo, J.R., Mason, A.T., Mason, L.H., Winkler-Pickett, R.T., Gosselin, P., and Anderson, S.K.: Selective inhibition of human and mouse NK-TR using retroviral anti-sense in primary NK cells: Involvement with MHC Class I killer cell inhibitory [KIR] receptors. J. Immunol, 150(3) 1262-1267.

Raziuddin, A., Longo, D.L., Mason, L., Ortaldo, J.R., and Murphy, W.J.: Ly-49 G2+ NK cells are responsible for mediating the rejection of H-2b bone marrow allografts in mice. Int. Immunol., 8: 1833-39,1996.

Nestel, F.P., Colwill, K., Harper, S., Pawson, T., and Anderson, S.K.: RS cyclophilins: Identification of an NK-TR1-related cyclophilin. Gene, 180 151-155.

Ortaldo, J.R., Winkler-Pickett, R.T., Nagata, S., and Ware, C.F.: Fas involvement in human NK cell apoptosis: Lack of a requirement for CD16 mediated events. J. Leukoc. Biol., 61(2) 209-215.

Simons-Evelyn, M., Young, H.A., and Anderson, S.K.: Characterization of the mouse Nktr gene and promoter. Genomics 40: 94-100, 1997.

Bosco, M.C., Rottschafer, S., Taylor, L.S., Ortaldo, J.R., Longo, D.L., and Espinoza-Delgado, I.: The antineoplastic agent bryostatin-1 induces proinflammatory cytokine production in human monocytes: synergy with Interleukin-2 and modulation of Interleukin-2R chain expression. Blood 89: 3402-3411, 1997.

Melillo, G., Taylor, L.S., Brooks, A., Musso, T., Cox, G.W., and Varesio, L.: Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine. J. Biol. Chem. 272: 12235-12243, 1997.

Taylor, L.S., Cox, G.W., Melillo, G., Bosco, M.C., and Espinoza-Delgado, I.: Bryostatin-1 and IFN- synergize for the expression of the inducible nitric oxide synthase gene and for nitric oxide production in murine macrophages. Cancer Res. 57: 2468-2473, 1997.

Conlon, K.C., Anver, M.R., Longo, D.L., Ortaldo, J.R., and Murphy, W.J.: Adoptive immunotherapy involving recombinant human M-CSF and R24 anti-melanoma antibody induces human T-cell infiltration into human melanoma xenografts. J. Immunother. Emphasis Tumor Immunol. 19: 317-323, 1996.

Ortaldo, J.R., Mason, L.H., Gregorio, T.A., Stoll, J. and Winkler-Pickett, R.T.: The Ly49 family: Regulation of cytokine production in murine NK cells. J. Leukoc. Biol., in press.

Grgurevich, S., Linnekin, D., Musso, T., Zhang, X., Modi, W., Varesio, L., Ruscetti, F.W., Ortaldo, J.R., and McVicar, D.W.: The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7E. Growth Factors, in press.

Last updated August 1997

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