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1. Researchers Find that a Small Molecule Can Activate an Important Cancer Suppressor Gene
(Posted: 05/01/2008) - By activating a cancer suppressor gene, a small molecule called nutlin-3a can block cancer cell division, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health. This activation of the p53 gene leads to cellular senescence, a process by which cells lose their ability to grow and divide. An opportunity for new genetic mutations occurs each time a cell divides, so limiting the number of cell divisions in a cancer cell inhibits tumor progression.
2. Mouse Studies Identify Gene that May Influence Metastasis Risk in Breast Cancer
(Posted: 04/21/2008) - Researchers have identified a pattern of gene activity in mice that may help to predict individual risk for breast cancer metastasis and survival in humans. A single gene called bromodomain 4 (Brd4) regulates the expression of this pattern, also called a signature. The researchers found that one result of this Brd4 regulation is the suppression of tumor growth and metastasis in a mouse model of cancer.
3. Mouse Studies Show Tumors Suppress Cells Responsible for Regulating the Immune System
(Posted: 04/18/2008) - New research has shown that the function of a type of cell that helps modulate immune responses is impaired inside tumors in mice.
4. Modified Virus Vaccine Shows Promise in Mouse Model of Breast Cancer
(Posted: 03/14/2008) - Researchers have shown that vaccinating mice with a modified form of a virus containing proteins from breast cancer cells can kill large breast cancer tumors and tumors that have spread to the lungs.
5. Studying Mutations in Non-Hodgkin Lymphoma Yields Clues for Potential New Therapies
(Posted: 03/06/2008) - DNA mutations found in a type of non-Hodgkin lymphoma that has a poor prognosis has led researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues to a better understanding of how the cancer develops and how it might be treated.
6. Newly Identified Genetic Variations May Affect Breast Cancer Risk
(Posted: 03/03/2008) - Researchers have identified genetic variations in a region of DNA that may be associated with risk for breast cancer. Women with the variation have a 1.4 times greater risk of developing breast cancer compared to those without this variation.
7. Changes in Adult Stem Cells May Underlie Rare Genetic Disease Associated with Accelerated Aging
(Posted: 03/02/2008) - Adult stem cells may provide an explanation for the cause of a Hutchinson-Gilford Progeris Syndrome (HGPS), a rare disease that causes premature aging in children, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).
8. New Study of Targeted Therapies for Breast Cancer Establishes Model for Global Clinical Trials
(Posted: 02/29/2008) - Two targeted medications designed to treat an aggressive form of breast cancer are being tested in a new study, called ALTTO, involving 8,000 participants in 50 countries across six continents -a clinical trial that investigators hope will provide a new model for global cancer research.
  
9. Tobacco Use, Secondhand Smoke Exposure during Pregnancy, May Threaten Health of Women and Children in Developing Nations
(Posted: 02/28/2008) - Findings from a National Institutes of Health (NIH) study indicate that rates of tobacco use during pregnancy, as well as exposure of pregnant women and their young children to secondhand smoke, are significant threats to health in several low and middle-income countries.
10. Smoking's Effects on Genes May Play a Role in Lung Cancer Development and Survival
(Posted: 02/19/2008) - Smoking plays a role in lung cancer development and now scientists have shown that smoking also affects the way genes are expressed, leading to alterations in cell division and regulation of immune response.
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